Kidney transplant error: Wrong patient got kidney at USC University Hospital – latimes.com
Come on guys. At least pretend you’e trying to be competent.

musings of a salt whisperer
Kidney transplant error: Wrong patient got kidney at USC University Hospital – latimes.com
Come on guys. At least pretend you’e trying to be competent.
Nate started the most important innovation in nephrology education since NephSAP, the Renal Fellow Network. Nate died, tragically, a year ago this past Sunday. We all stand on the shoulders of giants and Nate passed long before his work was done. In addition to thinking of Nate, we should also thank Matt Sparks and Conall O’ Seaghdha for picking up the pieces and transforming RFN from what was largely a one man show into the institution it has become.
Question: What is the most basic concept in clinical nephrology?
For the purpose of this post the renal function is synonymous with glomerular filtration rate.
Think about every lab measurment in clinical medicine and think about how the normal range changes as the GFR falls from 100 mL/min to 10 mL/min, a 90% reduction of renal function.
None of it lingers.
None of it accumulates in some creatinine depot in the subcutaneous fat or lateral horn of the cerebral ventricles.
This has to be true because if some of creatinine hung around and accumulated, the serum creatinine would rise. By definition, stable renal function means the creatinine doesn’t rise. So our 70 kg man generates 1,400 mg of creatinine and excretes 1,400 mg of creatinine.
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| President Bush is 5’11” |
You can use this spreadsheet below to predict the serum creatinine based on different GFRs, urine volumes and creatinine production. Try different urine volumes and see how that doesn’t affect the serum creatinine (the reason is that the numerator in the clearance formula is simply solving for the mass of creatinine excreted. Concentration of X multiplied by the volume gives amount of X dissolved in the solution.) . Use the spreadsheet to discover what Shaquile O’Neal’s serum creatinine is. Assume 20 mg/kg body weight, a weight of 147 kg, and a GFR of 120.
If you want to edit and use the equation image files download this Word file. Double click the equations to launch the equation editor.
The Michigan Department of Community Health has put together a great resource, High Blood Pressure University, which links to resources all about hypertension. The links are divided into three campuses:
I just added my third and last (?) tab to the blog. Books. It just has two items, The Fluid and Electrolyte Companion and the Michigan Hypertension Core Curriculum. Both are complete texts available as free PDFs. Check’em out.
I go slow when replacing potassium. I mean, they do use that stuff to execute people.
Jason Ye- orthopedic surgery intern
via Chinita Furiosa
Must read post about a recent Lancet paper comparing outcomes for patient treated for health care associated pneumonia (HCAP) and looked at outcomes based on adhering or non-adhering to the ATS and IDSA guidelines.
Spoiler alert: patients treated off guidelines did better.
I grabbed dinner with Matt Sparks, one of the driving forces behind the Renal Fellow Network. It was a great dinner and, for me, was the first time I had a chance to talk shop with another blogger. Very fun. One of the things we discussed was the role of blogs in fellow education (this idea was matured a little with a discussion with Conal O’ Seaghdha, the other half of inspiration that drives RFN.
I believe that the primary educational material for medical education has gone through three phases. In the beginning was the medical text book. This was exemplified by Harrisons which rose to ascendancy not by being the first text book but by being the most innovative. Harrison unique innovation was arranging the sections by patient complaint rather than by disease. Here it is described in a fascinating history of the Harrison family of doctors:
PRINCIPLES OF INTERNAL MEDICINE would offer medical students a new way of approaching patients. The Cecil Textbook of Medicine, which had previously monopolized the American medical textbook market, took a less helpful approach. Its author, Russell Cecil, M.D., of Cornell Medical School in New York, had organized the textbook exclusively by disease, offering the definition, cause, symptoms and signs, methods of diagnosis, treatment, and prognosis for each one. This meant, of course, that a student must identify the patient’s disease before the book would offer help. Principles of Internal Medicine, on the other hand, began with the patient. Tinsley [Harrison] devoted the first third of his textbook to symptoms and signs experienced by sick people, which included shortness of breath, swelling of the feet, and so on-leading from there to understanding the disease. The text mirrored the ideal practice of a physician. The first edition of his book, published in 1950, proved an instant and major success.
The second phase was UpToDate. Burton “Bud” Rose (how can Wikipedia not have an entry on Dr. Rose?) crushed the primary medical references by creating a comprehensive, readable and searchable reference. He also cajoled his authors to make specific treatment recommendations so Up-To-Date is the only medical reference that actually teaches you to take care of patients. One of my friends used to complain that when she would invest the hours and tears needed to read a chapter of Harrison’s she would finish with tremendous knowledge and the ability to shine on atending rounds but have no idea how to treat her patient. UpToDate is not like that and has probably saved more lives than ACLS. I routinely ask prospective fellows about their reference of choice and for three years running every single one of them has answered “UpToDate.”
As good as UpToDate is it has some weaknesses. The EBM zealots take it to task for relying on expert opinion but I really don’t have too much concern about that (my previous post on that took them to task for saying they are EBM when they are really an expert opinion source. That’s why the list of author/editors is so important and impressive. They should be proud of what they are rather than claim to be EBM) .
What concerns me is UpToDate’s inability to escape its CD-ROM DNA. I have been a subscriber to UpToDate since I was a resident and Burton Rose was still answering the phone to deal with bad CDs and pimping the still incomplete product in the hallways of Renal Week. The ascendancy of the Internet has allowed UpToDate to get out of the CD shipping business but they still refuse to link out even when it makes overwhelming sense. All of their articles are fully referenced, but not with links to the primary data or the pubmed reference but to an internal database record of the reference.
It feels that the editorial rules for UpToDate were created in the CD-ROM era of the 90’s and haven’t been updated for the internet era.
I beleive that, just as Harrison had an openning in the Internal Medicine textbook space by using patient oriented complaints to organize his text and Rose had an openning by using search and a unique editorial style, the technology of today provides a niche. I want an interactive textbook of medicine with comments, a Facebook “Like” button, a way to connect with other practitioners and share treatment pearls.
The renal fellow network and other knowledge focused medical blogs are early progenitors of this future but some pretty large problems need to be addressed:
– Posted using BlogPress from my iPad
Last week I posted on my pregnant patient who has Gitelman’s Syndrome. I am managing her with amiloride and a mixture of oral potassium and a mixture of oral and IV magnesium.
I received the following letter from a reader who went through a similar experience:
I am not a doctor, but I have Gitelman’s, and 16 years ago, was pregnant and ended up having to go on amiloride at the start of my second trimester, because my potassium and magnesium levels just tanked. Being part of proving the track record on the viability of amiloride in pregnancy was a scary time, I tell you what. Your patient’s experiences are similar to mine, though I did not require the magnesium IVs she apparently does during gestation.
The great news is my son turned out healthy, and without any sign of potassium disorders of any sort, so far as we can tell at nearly 16. He’s healthy, bright, nearly 6 ft – no indication at this time that he was harmed in any way by the fetal exposure to amiloride.
And another point to pass along – after he was born, I had my breast milk checked for traces of amiloride, and it passed whatever screens were applied. Therefore I nursed him for about 9 months, though I supplemented with formula. It was an acceptable risk for me – since I know the literature does not record any data on nursing while on amiloride, I thought I’d pass along one uncontrolled anecdote for you to ponder. [Note: on further communication the patient clarified that she did not take amiloride during breast feeding]
Anyway, please pass this information along to your patient – I am sure it will help her peace of mind to know another successful long term outcome. It was a scary time for me, and without the widespread use of Internet back in 1995, the only piece of mind I got was by tracking down Dr. Almeida, who wrote the 1989 paper about Gitelman’s in pregnancy. I spoke to one of his nurses to see if they could give me some info on long term followup on the baby, but the mother had disappeared after giving birth, and they had nothing to report.
Best of luck to your patient – I know what she’s going through.
Final note for your patient going forward: Getting my levels back up after the birth was a bit of a challenge, I recall. But many of the details have been lost to time and the fog of war, I’m afraid – I will just say that the first month post-partum was pretty rough on me.