Today I was honored to give Medicine Grand Rounds at MedStar Health in Baltimore. Here is a wlk through and bibliography for this talk.
Title slide. Slides are available for download at:
Keynote What’s New in Nephron Town (31.7 MB)
PowerPoint What’s New in Nephron Town (16.9 MB) Note: I create, rehearse and deliver the presentation in Keynote. The PowerPoint version is a simple export of the Keynote presentation and often looks like garbage. If you want to see the presentation as it was meant to be, use Keynote.
PDF What’s New in Nephron Town (9.8 MB) Note: The PDF shows only the final build of the slides and often that is not very illustrative of the point that the slide was trying to make. If you want to see the presentation as it was meant to be, use Keynote.
Outline of the talk. I originally outlined a section on aldosterone synthase inhibitors and IgA nephropathy, but ran out of time preparing for the lectures (aldosterone synthase) and thought it was not a great topic for general medicine audience (IgA nephroathy).
CDC data: SGLT2i use among Patients with CKD and Diabetes
Safety and Effectiveness of Bexagliflozin in Patients With Type 2 Diabetes Mellitus and Stage 3a/3b CKD AJKD
NO STONE Study: Dhayat, N. A. NEJM, 388(9), 781–791. (PubMed)
Craig Brater’s review of diuretics in the NEJM from 1998 (NEJM)
ALLHAT Hypertension results in JAMA. (PubMed)
CLICK Trial (PubMed)
The Diuretic Comparison Project. A pragmatic trial of HCTZ v chlorthalidone. (PubMed)
Meta-Analysis Comparing Torsemide Versus Furosemide in Patients With Heart Failure (PubMed)
TRANSFORM-HF Randomized Clinical Trial (PubMed)
AIN is a common finding on kidney biopsies done for AKI (at least at the University of Chicago, and among the elderly) (PubMed)
Urine eosinophils are not at diagnosing AIN. (PubMed)
Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis (PubMed)
Drug-Induced Acute Interstitial Nephritis. (CJASN)
Excellent review by the two guys who identified the gene. APOL1 Nephropathy from Genetics to Clinical Applications (CJASN)
Inaxaplin for Proteinuric Kidney Disease in Persons with Two APOL1 Variants (PubMed)
Link to information about free genetic test for APOL1 at APOL1CKD.com
The CONVINCE Trial (NEJM)
Retrospective data on the speed of correction from Pennsylvania (PubMed)
Toronto data showing a lack of association between speed of correction and incidence of ODS (NEJM Evidence)
Boston data looking at risk of mortality by speed of correction in hyponatremia. (NEJM Evidence)
Multi-center data also showing increased mortality with slow correction of hyponatremia. (J of Crit Care)