Month: October 2017

The Wikipedia entry for Journal Club used to have a comprehensive list of Twitter-based Journal Clubs. It looked like this

This past Saturday I gave a talk at the ACP of Michigan on SGLT2 inhibitors.

The talk went well, except my HDMI to thunderbolt converter failed in a big way and I had to export the presentation to Powerpoint and run it off a Windows Machine. Yuck.

I used visual abstracts from EMPA-REG and CANVAS as a significant part of the presentation. This segment demonstrates how I used them. What killed me was the cool animation, where the third panel flips to reveal the renal outcomes, was handled with complete incompetence by PowerPoint. Otherwise PowerPoint did a pretty good job displaying my slide, but botching my favorite animation in the entire presentation is bordering on unforgivable.

SGLT2i renal outcomes from joel topf on Vimeo.

Here are the two visual abstracts in question:

Exertional Rhabdomyolysis during a 246-km Continuous Running Race

SKENDERI, K. P., S. A. KAVOURAS, C. A. ANASTASIOU, N. YIANNAKOURIS and A. MATALAS. Exertional Rhabdomyolysis during a 246-km Continuous Running Race. Med. Sci. Sports Exerc., Vol. 38, No. 6, pp. 1054 – 1057, 2006. Background: To evaluate the effect of continuous, moderate-intensity ultraendurance running exercise on skeletal muscle and hepatic damage, as indicated by serum enzyme activity measured immediately following the race. Methods: Thirty-nine runners of the Spartathlon race (a 246-km continuous race from Athens to Sparta, Greece) who managed to complete the race within the 36-h limit participated in this study. Mean finishing time of the study participants was 33.3 T 0.5 h and their average age, height, and body mass were 41 T 1 yr, 174 T 1 cm, and 67.5 T 1.1 kg, respectively. Blood samples, taken a day before and immediately after completion of the race, were assayed for the following variables: creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyltransferase (F-GT). Results: A dramatic increase in most of muscle and liver damage indicators was observed. The mean values for CK, LDH, AST, and ALT after the race were 43,763 T 6,764, 2,300 T 285, 1,182 T 165, and 264 T 37 IUILj1, respectively. These values were 29,384 T 4,327, 585 T 89, 5,615 T 902, and 1,606 T 331% higher than the corresponding values before the race (P G 0.001) for CK, LDH, AST, and ALT, respectively. However, there was not a significant increase in F-GT levels. Conclusion: Muscle and liver damage indicators were elevated at the highest level ever reported as a result of prolonged exercise, although no severe symptoms that required hospitalization were observed in any of the participants. The data suggest that even moderate-intensity exercise of prolonged duration can induce asymptomatic exertional rhabdomyolysis. Key Words: CREATINE KINASE, LACTATE DEHYDROGENASE, SPARTATHLON, ULTRAENDURANCE EXERCISE

So tasty.

Link

This tweet has taken off.

What do you call a nephrologists who likes to go jogging?

A Nephrun. pic.twitter.com/51pGZ0vQJh

— Joel Topf, MD FACP (@kidney_boy) October 3, 2017

A few people have expressed an interest in getting one for themselves. Okay, I’m a reasonable guy. How about this deal.

If you are going to Kidney Week and you donate $50 to the Multiple Myeloma Research Foundation for my trip to Everest I will get you a t-shirt. Your donation is even tax-deductible. This needs to happen in the next 10 days for me to get the shirts in time.

If you are not going to Kidney Week, donate $100 and I will send you a shirt.

Want a shirt and you already donated to the MMRF? Shoot me a tweet (DM or @) or e-mail and we’ll work this out.

After you have donated, fill out this form so I get you the right shirt and know how to get it delivered.

The shirt is really nice. The women’s version is a Hanes Ladies Cool Dri V-Neck Performance Shirt and the mens is the same shirt, but crew neck.

Review of Gemcitabin (Gemzar) induced TTP

Link.