Albumin is made in hepatocytes at a rate of 200 mg/kg/day – Created with Haiku Deck, presentation software that inspires
Improving albumin levels among hemodialysis patients
- Albumin is made in hepatocytes at a rate of 200 mg/kg/day
- or 14 g in 70 kg person
- Total body albumin is 4-5 g/kg
- 40-45% of albumin is in the intravascular space
- Normal albumin concentration in the interstitial space is
- 0.7 in fat and
- 1.3 in skeletal muscle
- Albumin has a half life of 2 to 3 weeks
- The drop in albumin with inflammation is due to:
- reduced synthesis and
- increased fractional catabolic rate (FCR)
- Intradialytic weight gain of 2.8 liters (4% in a 70 kg man) will dilute the albumin down 0.8 g/dL
Refs
Improving albumin levels among hemodialysis patients (PubMed)
Measurement of interstitial albumin in human skeletal muscle and adipose tissue by open-flow micro perfusion (PubMed)