My camping club, Aggressive Deer Adventures had a great trip to Kings Canyon National Park. The group consisted of 7 men, all 40-something who lived at around 600 feet above sea level. The whole trip took place between eight thousand and twelve thousand feet.
Every one started on low dose acetazolamide (125 mg bid) 36 hours before we left home.
Not one of us developed anything more than a small headache on travel day. Complete success.