For the sixth year I have had the privledge of teaching at OUWB. When I teach I get e-mail questions from the students. I respond to the students by e-mail but also post the questins and answers here so all the students get the advantages of the questions.
Caller one you are on the line…
“Long time listener; First time caller. Some of the M3s were telling us that last year, they were confused on this Team Based Learning exercise because they learned hyponatremic means low water/volume but originally they thought it meant low salt, and hypovolemic means low salt but they thought it meant low water/volume.
Could you explain? A lot of us are confused now…”
The conflation of volume and osmolality is always confusing.
Hyponatremia means a low sodium concentration.
Hypovolemia means a low total body sodium (literally the total number of grams of sodium in the body). Hypovolemia does not say anything about the concentration of that sodium.
That low total body sodium may be at a high a high or low concentration depending on what the total body water is.
For example heart failure is a common cause of hyponatremia. These patients have edema and other evidence of volume overload. This is a combination of volume overload and hyponatremia. Increased total body sodium, but even great increase in total body water.
Patients with severe diarrhea also can develop hyponatremia. In this case they are volume depleted, decreased total body sodium.
And lastly, patients with SIADH, say from small cell lung cancer, are euvolemic and have a normal total body sodium*.
You can’t equate the two, just like saying that a bowl of soup is salty doesn’t explain how big the bowl is. If the soup is salty but you have only a spoonful, there is not much salt.
Hope this is helpful.
“Hi Dr. Topf,
I hope your day has been going well! I was reading over the TBL preparatory material for tomorrow and came across a point that was slightly confusing.
Could you please clarify what exactly was meant by the following:
“Clinicians often characterize hyponatremia by the volume status, hypovolemic hyponatremia versus hypervolemic hyponatremia. It should be clear that both of those two seemingly different causes of hyponatremia, share a single patho- physiologic explanation.”
I’ll hang up and take my answer off the line.”
Thanks for calling. Great question. This was covered in this slide from my second lecture:
The point of the slide and that both hypovolemic (on the left) and hypervolemic (on the right) cause hyponatremia by the same physiologic mechanism:
1. decreased perfusion (from heart failure in hypervolemic and volume depletion in hypovolemic)
2. Release of ADH (due to the low perfusion, not a high osmolality)
3. Decreased urine output
4. Water intake > urine output
Is that clear?
Hello Dr. Topf,
Please, call me @Kidney_Boy.
Hope you’re doing well. I really enjoyed your lectures today. I was studying for our upcoming class on Friday where we are going to be quizzed on a lot of the same information and I became a little confused. In the TBL article (pg 12) there is a figure and a paragraph that says glucose induced hyponatremia is a type of pseudo-hyponatremia. However it also defines pseudo-hyponatremia as a decreased serum sodium with a normal serum osmolality.
Is the glucose induced factitious hyponatremia is a kind of pseudo-hyponatremia ? If so how can it be a pseudo-hyponatremia when the glucose causes an osmolality imbalance?
Thank you so much.
This one is one me. The TBL document needs to be updated This is just a nomenclature issue.
There is some ambiguity on whether glucose induced hyponatremia can be called pseudohyponatremia, there is some support for it and I used to be in that camp (in fact I wrote a whole book about fluid electrolytes waving the glucose induced pseudohyponatremia flag) but most people limit the term pseudohyponatremia to just the high protein and high lipids causing the lab error (sometimes called a lab artifact), and separate out the high osmolar causes under a different category (factitious hyponatremia).
So I would study what I taught in lecture today. Understanding concepts is more important than knowing the specific names.
Obligatory blog post about the subject (see the segment after the Update):
Hope that helps.
That really clears things up for me! Thank you so much!
That’s all we have time for. Until next time…