musings of a salt whisperer
About three years ago I had the privledge to attend a day long seminar on gout put together by Jerry Yee from Henry Ford Hospital. The highlight of the day was a lecture by Richard Johnson from the University of Florida. I had learned about Johnson at my fellowship as the principle discoverer of the …
Continue reading “I am doing Grand-Rounds on the relationship of uric acid and hypertension”
Uric Acid, Gout and Hypertension (Keynote, PDF) For awhile I was really fascinated with this subject. Here are the posts I wrote on the topic. Updated June 2011 Added CKD data included the two RCTs of allopurinol on CKD progression (both positive) 121 slides Keynote is 96mb, PDF 59mb You can do it in an hour, …
Okay nephrologists, we have suffered the slings and arrows of outrageous trial after trial going against us. It is time to put down those depressing journals full of non-significant P values and stretch our imagination. It is time to design our own dream randomized controlled trial. The assignment is to target the most important question …
Continue reading “#DreamRCT: Prove the uric acid-CKD connection and win Richard Johnson a Nobel”
I have written and presented quite a bit about uric acid, fructose and the link to hypertension and chronic kidney disease. Last month’s Kidney International published an interesting take on this subject. The question that the investigators were examining was, “Is uric acid a cause of hypertension?” The data supporting this is largely epidemiologic, with …
Continue reading “Uric acid and hypertension, a unique study”
For the last 6 weeks I have been pounding the computer finishing and perfecting my lecture which I gave at Grand Rounds at both Providence Hospital and St John’s Hospital. I delivered the second one yesterday. Here is the lecture with an audio track. My presentations are not self-contained most of the important data comes …
Today, I gave grand-rounds at William Beaumont Hospital Royal Oak. I gave the fructose-uric acid lecture I gave in January of 2010. Over the last 16 months, the science has continued to move forward without any hiccups. Additionally, data supporting direct renal toxicity of fructose and uric acid has matured. This latest version of the …
Continue reading “Fructose, hypertension and CKD: an update”
In my grand rounds on uric acid’s link to renal disease and hypertension I was not able to show any compelling data that allopurinol actually helped adults. There is convincing data on the use of allopurinol for the treatment of adolescent hypertension. The only adult data I could find was a VA study which used a retrospecitve …
Continue reading “Allopurinol a novel way to slow the progression of chronic kidney disease”
I wrote an article for this month’s news letter for my practise, SCSP. I wrote it on the work I did for my grand rounds. Enjoy. in 1964 Walt Disney purchased The “It’s a Small World” ride from the New York World’s Fair. It became a staple of the American experience and became as beloved …
March 21 Providence MS3: Acid-Base February 28 Providence MS3: Sodium January 24 Providence MS3: Body WaterJanuary 3 St John Hospital Residency: Potassium2014 December 12 St John Nephrology Fellowship: ASN Kidney Week: reviewed.December 11 Mclaren Macomb: potassium and alkalosisDecember 6 St John Hospital Residency: AKIDecember 5 St John Nephrology Fellowship: NephSAP November 26 Providence Hospital Internal …