This is one of my favorite lectures. It starts with Izzy getting fired on Grey’s Anatomy to the metabolic consequences of crack cocaine in dialysis patients to the imaginary monogenic diseases of Ethan Hawke and Denzel Washington. Metabolic alkalosis is a topic that is rarely taught at all. This lecture goes deep tying metabolic alkalosis to potassium handling (as does the kidney). The lecture covers a lot of useful kidney physiology. In addition to metabolic alkalosis it covers some of the salt wasting nephropathies and monogenic causes of hypertension.