I’m giving grand rounds on Tuesday on SGLT2 inhibitors and I’m trying to come up with a list of therapies that lower CV death in diabetes.
Here is my list:
- Blood pressure control
- CANVAS Only partial credit here. CV death was part of the composite outcome, but CVD was not significant on its own
- SUSTAIN-6 Weak. Hit the primary outcome but CV death was explicitly identical between groups
Drugs that have run the FDA CV disease gauntlet and that are non-inferior to standard of care:
- EXAMINE (This is a secondary prevention trial. As far as I can tell it is the only FDA mandated outcome trial that is specifically designed as a secondary prevention. Not sure why.)
I’m sure I’m missing some. There must be a statin trial of diabetics. Right?
Swapnil was first with the statin answer:
— Swapnil Hiremath, MD (@hswapnil) December 3, 2017
And Edgar came up with a great visual from a review paper:
— Edgar V. Lerma 🇵🇭 (@edgarvlermamd) December 3, 2017
And Szymon came up with the Steno trial. I can’t believe I forgot about that one.
— Szymon Brzósko (@brzoskos) December 3, 2017