Lecture on autosomal dominant polycystic kidney disease

My practice has a number of nurse practitioners and physician assistants. The partners do quarterly teaching sessions for them. It is some of my favorite teaching. They come to each session with a lot of experience and the sessions are more like guided conversations rather than traditional lectures. I usually try to frame the session with a clinical practice guideline and we just go through it step by step. This time I did autosomal dominant polycystic kidney disease. I couldn’t find a clinical practice guideline, so I just went with the KDIGO Controversies paper and went from there.

Update from Twitter (where else?)

You mentioned in your post there is no CPG in ADPKD. There is a Canadian one recently published:https://t.co/TFBeI0Kw02

— Dr. Jordan Weinstein (@drjjw) June 5, 2017

The slides:

We use these to make sure we cover all aspects of the disease during the session. They really don’t stand alone. They serve primarily as an outline of the conversation.

9 mb Keynote | 4.7 mb PowerPoint | 5.4 mb PDF

The bibliography:

  1. Clinical practice. Autosomal dominant polycystic kidney disease (PubMed)
  2. Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference (PDF)
  3. Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease HALT-PKD (PubMed)
  4. Extended Follow-Up of Unruptured Intracranial Aneurysms Detected by Presymptomatic Screening in Patients with Autosomal Dominant Polycystic Kidney Disease (PMC full text)
  5. KHA-CARI Autosomal Dominant Polycystic Kidney Disease Guideline: Management of Renal Stone Disease (PDF)
  6. The Natural Course of Unruptured Cerebral Aneurysms in a Japanese Cohort (NEJM)
  7. Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease TEMPO 3:4 (NEJM)

The Tweets:

Look at this chart from KDIGO ADPKD conference. Looks like there are mistakes. pic.twitter.com/IYJE2vWbaU

— Joel Topf, MD FACP (@kidney_boy) June 2, 2017

Specificity should rise with a lack of cysts at higher ages, why is it going own? Thoughts @goKDIGO

— Joel Topf, MD FACP (@kidney_boy) June 2, 2017

Cat making it hard to finish my presentation pic.twitter.com/4sMRVjPbwN

— Joel Topf, MD FACP (@kidney_boy) June 2, 2017

In casse you always wanted to know what 50 pounds of kidneys looks like https://t.co/qxvVeVsBf8 pic.twitter.com/truZRQxznI

— Joel Topf, MD FACP (@kidney_boy) June 2, 2017

Best summary in this review of ADPKD liver involvement is: “huge, silent, and durable”https://t.co/ZXwWJDRaMA

— Joel Topf, MD FACP (@kidney_boy) June 2, 2017

The GFR lies to you in ADPKD. See the late MRI image…the GFR is normal.https://t.co/Zk2HCegvpB pic.twitter.com/vwXhUmFjQD

— Joel Topf, MD FACP (@kidney_boy) June 2, 2017

The Cake:

The NPs andPAs bought me a cake for winning the Robert Narins Award. So nice.