One Reply to “Twitter conversation: Hyponatremia and Osteoporosis”
A 1/3 of total body sodium is non exchangeable and is found in bones. In situations of chronic hyponatremia, sodium leaves the bones to compensate for low serum sodium. This somehow activates osteoclastic activity and increases bone resorption. So, now there are multiple mechanisms for fractures in hyponatremia: osteoporosis, falls, gait disturbances. And this happens with mild hyponatremia. I believe the term "asymptomatic" hyponatremia is not valid anymore.
A 1/3 of total body sodium is non exchangeable and is found in bones. In situations of chronic hyponatremia, sodium leaves the bones to compensate for low serum sodium. This somehow activates osteoclastic activity and increases bone resorption. So, now there are multiple mechanisms for fractures in hyponatremia: osteoporosis, falls, gait disturbances. And this happens with mild hyponatremia. I believe the term "asymptomatic" hyponatremia is not valid anymore.